Antifolate resistance

hsa01523 24 targets in this pathway

UniProt AC Gene Protein Name Organism Multi-Target Molecules
P00374 DHFR Dihydrofolate reductase Homo sapiens 477 Detail
O14920 IKBKB Inhibitor of nuclear factor kappa-B kinase subunit beta Homo sapiens 411 Detail
O15111 CHUK Inhibitor of nuclear factor kappa-B kinase subunit alpha Homo sapiens 170 Detail
P01584 IL1B Interleukin-1 beta Homo sapiens 148 Detail
P01375 TNF Tumor necrosis factor Homo sapiens 144 Detail
P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 140 Detail
Q04206 RELA Transcription factor p65 Homo sapiens 134 Detail
P04818 TYMS Thymidylate synthase Homo sapiens 103 Detail
P14207 FOLR2 Folate receptor beta Homo sapiens 60 Detail
P15328 FOLR1 Folate receptor alpha Homo sapiens 56 Detail
Q9UNQ0 ABCG2 Broad substrate specificity ATP-binding cassette transporter Homo sapiens 52 Detail
P22102 GART Trifunctional purine biosynthetic protein adenosine-3 Homo sapiens 46 Detail
Q96NT5 SLC46A1 Proton-coupled folate transporter Homo sapiens 34 Detail
P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial Homo sapiens 32 Detail
P34896 SHMT1 Serine hydroxymethyltransferase, cytosolic Homo sapiens 29 Detail
P41440 SLC19A1 Reduced folate transporter Homo sapiens 25 Detail
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens 23 Detail
P05231 IL6 Interleukin-6 Homo sapiens 17 Detail
Q9Y6K9 IKBKG NF-kappa-B essential modulator Homo sapiens 13 Detail
P31939 ATIC Bifunctional purine biosynthesis protein ATIC Homo sapiens 10 Detail
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 Homo sapiens 3 Detail
Q05932 FPGS Folylpolyglutamate synthase, mitochondrial Homo sapiens 2 Detail
Q99707 MTR Methionine synthase Homo sapiens 1 Detail
O15438 ABCC3 ATP-binding cassette sub-family C member 3 Homo sapiens 1 Detail