Endocrine resistance
hsa01522 74 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P11802 |
CDK4 | Cyclin-dependent kinase 4 | Homo sapiens | 2896 | Detail |
P08253 |
MMP2 | 72 kDa type IV collagenase | Homo sapiens | 2719 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P04626 |
ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens | 2123 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
P14780 |
MMP9 | Matrix metalloproteinase-9 | Homo sapiens | 1941 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
Q16539 |
MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens | 1754 | Detail |
P24385 |
CCND1 | G1/S-specific cyclin-D1 | Homo sapiens | 1643 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P03372 |
ESR1 | Estrogen receptor | Homo sapiens | 1446 | Detail |
Q92731 |
ESR2 | Estrogen receptor beta | Homo sapiens | 1440 | Detail |
Q00987 |
MDM2 | E3 ubiquitin-protein ligase Mdm2 | Homo sapiens | 1334 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
P04637 |
TP53 | Cellular tumor antigen p53 | Homo sapiens | 1173 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P45983 |
MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens | 748 | Detail |
P45984 |
MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens | 676 | Detail |
P53779 |
MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens | 625 | Detail |
P08069 |
IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens | 611 | Detail |
P53778 |
MAPK12 | Mitogen-activated protein kinase 12 | Homo sapiens | 606 | Detail |
P10635 |
CYP2D6 | Cytochrome P450 2D6 | Homo sapiens | 601 | Detail |
Q15759 |
MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens | 594 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O15264 |
MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens | 533 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P17612 |
PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens | 453 | Detail |
Q05397 |
PTK2 | Focal adhesion kinase 1 | Homo sapiens | 325 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P22694 |
PRKACB | cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens | 121 | Detail |
Q86X55 |
CARM1 | Histone-arginine methyltransferase CARM1 | Homo sapiens | 120 | Detail |
P22612 |
PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens | 111 | Detail |
P46531 |
NOTCH1 | Neurogenic locus notch homolog protein 1 | Homo sapiens | 84 | Detail |
P05412 |
JUN | Transcription factor Jun | Homo sapiens | 69 | Detail |
O75376 |
NCOR1 | Nuclear receptor corepressor 1 | Homo sapiens | 58 | Detail |
Q9UM47 |
NOTCH3 | Neurogenic locus notch homolog protein 3 | Homo sapiens | 53 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
Q08828 |
ADCY1 | Adenylate cyclase type 1 | Homo sapiens | 30 | Detail |
P40145 |
ADCY8 | Adenylate cyclase type 8 | Homo sapiens | 27 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
P01100 |
FOS | Protein c-Fos | Homo sapiens | 25 | Detail |
O95622 |
ADCY5 | Adenylate cyclase type 5 | Homo sapiens | 23 | Detail |
Q08462 |
ADCY2 | Adenylate cyclase type 2 | Homo sapiens | 21 | Detail |
O60266 |
ADCY3 | Adenylate cyclase type 3 | Homo sapiens | 21 | Detail |
O43306 |
ADCY6 | Adenylate cyclase type 6 | Homo sapiens | 21 | Detail |
P51828 |
ADCY7 | Adenylate cyclase type 7 | Homo sapiens | 21 | Detail |
O60503 |
ADCY9 | Adenylate cyclase type 9 | Homo sapiens | 21 | Detail |
Q8NFM4 |
ADCY4 | Adenylate cyclase type 4 | Homo sapiens | 21 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
Q99527 |
GPER1 | G-protein coupled estrogen receptor 1 | Homo sapiens | 9 | Detail |
P06400 |
RB1 | Retinoblastoma-associated protein | Homo sapiens | 8 | Detail |
O95342 |
ABCB11 | Bile salt export pump | Homo sapiens | 6 | Detail |
Q9Y6Q9 |
NCOA3 | Nuclear receptor coactivator 3 | Homo sapiens | 5 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P38936 |
CDKN1A | Cyclin-dependent kinase inhibitor 1 | Homo sapiens | 1 | Detail |
Q04721 |
NOTCH2 | Neurogenic locus notch homolog protein 2 | Homo sapiens | 1 | Detail |
Q99466 |
NOTCH4 | Neurogenic locus notch homolog protein 4 | Homo sapiens | 1 | Detail |
Q15648 |
MED1 | Mediator of RNA polymerase II transcription subunit 1 | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |