EGFR tyrosine kinase inhibitor resistance
hsa01521 61 targets in this pathway
| UniProt AC | Gene | Protein Name | Organism | Multi-Target Molecules | |
|---|---|---|---|---|---|
O60674 |
JAK2 | Tyrosine-protein kinase JAK2 | Homo sapiens | 10545 | Detail |
P23458 |
JAK1 | Tyrosine-protein kinase JAK1 | Homo sapiens | 8920 | Detail |
P35968 |
KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens | 5667 | Detail |
P42336 |
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 5616 | Detail |
O00329 |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 3772 | Detail |
P00533 |
EGFR | Epidermal growth factor receptor | Homo sapiens | 3433 | Detail |
P22607 |
FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens | 2742 | Detail |
P15056 |
BRAF | Serine/threonine-protein kinase B-raf | Homo sapiens | 2643 | Detail |
P27986 |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens | 2553 | Detail |
P42345 |
MTOR | Serine/threonine-protein kinase mTOR | Homo sapiens | 2517 | Detail |
P49841 |
GSK3B | Glycogen synthase kinase-3 beta | Homo sapiens | 2206 | Detail |
P04049 |
RAF1 | RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens | 2133 | Detail |
P21802 |
FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens | 2130 | Detail |
P04626 |
ERBB2 | Receptor tyrosine-protein kinase erbB-2 | Homo sapiens | 2123 | Detail |
P12931 |
SRC | Proto-oncogene tyrosine-protein kinase Src | Homo sapiens | 1978 | Detail |
P42338 |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic sub | Homo sapiens | 1951 | Detail |
O43521 |
BCL2L11 | Bcl-2-like protein 11 | Homo sapiens | 1888 | Detail |
P01116 |
KRAS | GTPase KRas | Homo sapiens | 1811 | Detail |
P30530 |
AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens | 1661 | Detail |
P31749 |
AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens | 1633 | Detail |
P09619 |
PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens | 1527 | Detail |
P23443 |
RPS6KB1 | Ribosomal protein S6 kinase beta-1 | Homo sapiens | 1180 | Detail |
P08581 |
MET | Hepatocyte growth factor receptor | Homo sapiens | 1125 | Detail |
P10415 |
BCL2 | Apoptosis regulator Bcl-2 | Homo sapiens | 1065 | Detail |
Q07817 |
BCL2L1 | Bcl-2-like protein 1 | Homo sapiens | 990 | Detail |
P01111 |
NRAS | GTPase NRas | Homo sapiens | 923 | Detail |
P28482 |
MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens | 906 | Detail |
P31751 |
AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens | 896 | Detail |
P16234 |
PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens | 860 | Detail |
Q07889 |
SOS1 | Son of sevenless homolog 1 | Homo sapiens | 766 | Detail |
P17252 |
PRKCA | Protein kinase C alpha type | Homo sapiens | 679 | Detail |
P08069 |
IGF1R | Insulin-like growth factor 1 receptor | Homo sapiens | 611 | Detail |
Q02750 |
MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens | 543 | Detail |
O00459 |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | Homo sapiens | 485 | Detail |
P05771 |
PRKCB | Protein kinase C beta type | Homo sapiens | 457 | Detail |
Q13541 |
EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein | Homo sapiens | 358 | Detail |
Q9Y243 |
AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens | 321 | Detail |
P05129 |
PRKCG | Protein kinase C gamma type | Homo sapiens | 311 | Detail |
Q92569 |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | Homo sapiens | 289 | Detail |
P27361 |
MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens | 234 | Detail |
Q14393 |
GAS6 | Growth arrest-specific protein 6 | Homo sapiens | 231 | Detail |
P36507 |
MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens | 146 | Detail |
P21860 |
ERBB3 | Receptor tyrosine-protein kinase erbB-3 | Homo sapiens | 109 | Detail |
P09038 |
FGF2 | Fibroblast growth factor 2 | Homo sapiens | 69 | Detail |
P40763 |
STAT3 | Signal transducer and activator of transcription 3 | Homo sapiens | 49 | Detail |
P06730 |
EIF4E | Eukaryotic translation initiation factor 4E | Homo sapiens | 46 | Detail |
P15692 |
VEGFA | Vascular endothelial growth factor A, long form | Homo sapiens | 44 | Detail |
P10398 |
ARAF | Serine/threonine-protein kinase A-Raf | Homo sapiens | 37 | Detail |
Q92934 |
BAD | Bcl2-associated agonist of cell death | Homo sapiens | 27 | Detail |
P05231 |
IL6 | Interleukin-6 | Homo sapiens | 17 | Detail |
P01127 |
PDGFB | Platelet-derived growth factor subunit B | Homo sapiens | 16 | Detail |
P01112 |
HRAS | GTPase HRas | Homo sapiens | 14 | Detail |
P62753 |
RPS6 | Small ribosomal subunit protein eS6 | Homo sapiens | 13 | Detail |
Q9UBS0 |
RPS6KB2 | Ribosomal protein S6 kinase beta-2 | Homo sapiens | 13 | Detail |
P62993 |
GRB2 | Growth factor receptor-bound protein 2 | Homo sapiens | 4 | Detail |
P14210 |
HGF | Hepatocyte growth factor | Homo sapiens | 4 | Detail |
Q13480 |
GAB1 | GRB2-associated-binding protein 1 | Homo sapiens | 2 | Detail |
P19174 |
PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P16885 |
PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga | Homo sapiens | 2 | Detail |
P04085 |
PDGFA | Platelet-derived growth factor subunit A | Homo sapiens | 1 | Detail |
Q07812 |
BAX | Apoptosis regulator BAX | Homo sapiens | 1 | Detail |